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Pharmacologically, modulating histone acetylation with LAC rapidly increased xCT and activated a network with mGlu2 receptors to prime enhanced glutamate homeostasis that promotes both pro-resilient and antidepressant-like responses (101)

We also highlight major challenges in CHE management, including limited implementation of testing, inadequate biomarkers, diagnostic difficulties in geriatric cirrhosis, and unmet needs in fall and driving risk management, and emphasize the importance of multidisciplinary team-based approaches to improve patient outcomes